You Tae-Min, Choi Byung-Ho, Zhu Shi-Jiang, Jung Jae-Hyung, Lee Seoung-Ho, Huh Jin-Young, Lee Hyun-Jung, Li Jingxu
Graduate Student, Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
Int J Oral Maxillofac Implants. 2007 May-Jun;22(3):417-22.
The aim of this study was to compare the effects of platelet-enriched fibrin glue and platelet-rich plasma (PRP) on the repair of bone defects adjacent to titanium dental implants.
In 6 mongrel dogs, 3 screw-shaped titanium dental implants per dog were placed into the osteotomy sites in the tibia. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bone walls. Six gaps were left empty (control group), 6 gaps were filled with autogenous particulate bone mixed with PRP (PRP group), and 6 gaps were filled with autogenous particulate bone mixed with platelet-enriched fibrin glue (fibrin glue group).
After 6 weeks, the bone-implant contact was 59.7% in the fibrin glue group, 29.2% in the PRP group, and 10.2% in the control defects; this difference was statistically significant (P < .05).
Greater bone-implant contact was achieved with platelet-enriched fibrin glue than with PRP. The results indicate that platelet-enriched fibrin glue can induce a stronger peri-implant bone reaction than PRP in the treatment of bone defects adjacent to titanium dental implants.
本研究旨在比较富血小板纤维蛋白胶和富血小板血浆（PRP）对钛牙种植体周围骨缺损修复的影响。
选用6只杂种犬，每只犬在胫骨截骨部位植入3枚螺旋形钛牙种植体。植入前，在种植体表面与周围骨壁之间制造一个标准化间隙（2.0毫米）。6个间隙不做处理（对照组），6个间隙填充自体颗粒骨与PRP的混合物（PRP组），6个间隙填充自体颗粒骨与富血小板纤维蛋白胶的混合物（纤维蛋白胶组）。
6周后，纤维蛋白胶组的骨-种植体接触率为59.7%，PRP组为29.2%，对照缺损组为10.2%；差异具有统计学意义（P < .05）。
富血小板纤维蛋白胶比PRP能实现更大的骨-种植体接触。结果表明，在治疗钛牙种植体周围骨缺损时，富血小板纤维蛋白胶比PRP能诱导更强的种植体周围骨反应。
