Amlund Heidi, Ingebrigtsen Kristian, Hylland Ketil, Ruus Anders, Eriksen Dag Øistein, Berntssen Marc H G
National Institute of Nutrition and Seafood Research, Bergen, Norway.
Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jun;143(2):171-8. doi: 10.1016/j.cbpc.2006.01.007. Epub 2006 Mar 20.
The distribution and excretion of arsenobetaine in fish were investigated using whole body autoradiography and liquid scintillation counting. A single dose of synthesised [(14)C]arsenobetaine was orally administered to Atlantic salmon, Salmo salar L., and Atlantic cod, Gadus morhua L. Arsenobetaine was distributed to most organs within both species. Nevertheless, there were species differences in tissue distribution and excretory pattern. The highest level of arsenobetaine in Atlantic salmon was present in muscle tissue, while high levels of arsenobetaine were found in both muscle and liver (including gall bladder) from Atlantic cod. The results suggest that the major route of excretion was via urine, which seemed to be more important in Atlantic cod than in Atlantic salmon. Elimination of arsenobetaine via bile appeared to be negligible in both species.
采用全身放射自显影术和液体闪烁计数法，对鱼类中砷甜菜碱的分布和排泄情况进行了研究。给大西洋鲑（Salmo salar L.）和大西洋鳕鱼（Gadus morhua L.）口服单剂量合成的[(14)C]砷甜菜碱。砷甜菜碱在这两个物种的大多数器官中都有分布。然而，在组织分布和排泄模式上存在物种差异。大西洋鲑中砷甜菜碱含量最高的是肌肉组织，而在大西洋鳕鱼的肌肉和肝脏（包括胆囊）中都发现了高含量的砷甜菜碱。结果表明，排泄的主要途径是通过尿液，这在大西洋鳕鱼中似乎比在大西洋鲑中更重要。在这两个物种中，通过胆汁消除砷甜菜碱的情况似乎可以忽略不计。
