Vendramini Marcio F, Ferreira Sandra R G, Gimeno Suely G A, Kasamatsu Teresa S, Miranda Walkiria L, Moisés Regina S
Division of Endocrinology, Department of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
Diabetes Res Clin Pract. 2006 Sep;73(3):304-9. doi: 10.1016/j.diabres.2006.02.002. Epub 2006 Mar 20.
The objective of this study was to investigate whether decreased baseline adiponectin levels are an independent risk factor for development of glucose intolerance in a population-based study of Japanese-Brazilians, a group with one of the highest prevalence rates of diabetes worldwide. We examined 210 Japanese-Brazilians (97 male and 113 female, aged 56.7+/-10.1 years) with normal glucose tolerance (NGT). Plasma adiponectin, insulin, fasting and 2-h plasma glucose and lipid profile were evaluated at baseline and also at 7-year follow-up. Plasma adiponectin levels were significantly lower in glucose intolerance progressors compared with subjects who remained NGT. By increasing tertiles of adiponectin, the frequencies of subjects who progressed to glucose intolerance were 40%, 33% and 27% and the frequencies of subjects who remained NGT were 13%, 35% and 52% (chi2=15.8, p=0.001). Logistic regression analyses showed that adiponectin levels (OR for the highest versus lowest tertile: 0.31; 95% CI: 0.12-0.84, p=0.021), male sex (OR: 2.61, 95% CI: 1.21-5.65, p=0.015), fasting plasma glucose (0R: 3.05, 95% CI: 1.35-6.91, p=0.008) and waist circumference (OR: 1.04, 95% CI: 1.00-1.08, p=0.046) were independent risk factors for the progression to glucose intolerance. In conclusion, low plasma levels of adiponectin is one of several independent predictors of glucose intolerance in a Japanese-Brazilian population.
本研究的目的是在一项针对日裔巴西人的基于人群的研究中调查基线脂联素水平降低是否是葡萄糖不耐受发展的独立危险因素，日裔巴西人群是全球糖尿病患病率最高的群体之一。我们检查了210名糖耐量正常（NGT）的日裔巴西人（97名男性和113名女性，年龄56.7±10.1岁）。在基线以及7年随访时评估血浆脂联素、胰岛素、空腹及2小时血浆葡萄糖和血脂谱。与仍保持糖耐量正常的受试者相比，葡萄糖不耐受进展者的血浆脂联素水平显著更低。随着脂联素三分位数增加，进展为葡萄糖不耐受的受试者频率分别为40%、33%和27%，仍保持糖耐量正常的受试者频率分别为13%、35%和52%（χ2=15.8，p=0.001）。逻辑回归分析显示，脂联素水平（最高三分位数与最低三分位数相比的比值比：0.31；95%置信区间：0.12 - 0.84，p=0.021）、男性（比值比：2.61，95%置信区间：1.21 - 5.65，p=0.015）、空腹血糖（比值比：3.05，95%置信区间：1.35 - 6.91，p=0.008）和腰围（比值比：1.04，95%置信区间：1.00 - 1.08，p=0.046）是进展为葡萄糖不耐受的独立危险因素。总之，血浆脂联素水平低是日裔巴西人群中葡萄糖不耐受的几个独立预测因素之一。
