Gimeno S G A, Ferreira S R G, Franco L J, Hirai A T, Matsumura L, Moisés R S
Preventive Medicine Department, Federal University of São Paulo (UNIFESP-EPM), Brazil.
Diabetologia. 2002 Dec;45(12):1635-8. doi: 10.1007/s00125-002-0963-x. Epub 2002 Oct 24.
AIMS/HYPOTHESIS: In 1993, the prevalence of glucose intolerance was studied in a sample of 647 first-generation and second-generation Japanese-Brazilians. Their cohort was followed until 2000, when a second survey was conducted, this included the first and second generations, aged 30 or more years. The aims were to estimate the prevalence of glucose intolerance and 7-yr incidence of Type II (non-insulin-dependent) diabetes mellitus in this population.
Prevalence rates were obtained for 1330 subjects examined in 2000. The incidence of diabetes mellitus was calculated for those classified as normal glucose tolerant in 1993 (n=253). A Student's t test and the Cox proportional hazard model were used in data analysis.
In the year 2000, higher proportions of subjects were observed in all categories of glucose intolerance than those found in 1993. The overall incidence of diabetes was 30.9 per 1000 per year. A worse profile was observed among incident cases of diabetes, characterized by higher baseline values of anthropometric and metabolic variables as compared to those who had not developed diabetes. Analysis considering the simultaneous effects of demographic, nutritional and metabolic variables and physical activity levels for the development of diabetes showed that age, sex, waist circumference, fasting and 2-h plasma glucose concentrations were independent predictors.
CONCLUSION/INTERPRETATION: Our data point towards a worsening of glucose tolerance status among Japanese-Brazilians, who show one of the highest prevalence rates of diabetes mellitus worldwide. This could reflect their strong genetic susceptibility associated with unfavourable environmental conditions.
目的/假设：1993年，对647名第一代和第二代日裔巴西人样本进行了葡萄糖耐量异常患病率的研究。对他们的队列进行随访直至2000年，当时进行了第二次调查，此次调查涵盖了30岁及以上的第一代和第二代人群。目的是估计该人群中葡萄糖耐量异常的患病率以及II型（非胰岛素依赖型）糖尿病的7年发病率。
获取了2000年接受检查的1330名受试者的患病率。计算了1993年被分类为葡萄糖耐量正常者（n = 253）的糖尿病发病率。数据分析采用了学生t检验和Cox比例风险模型。
2000年时，在所有葡萄糖耐量异常类别中观察到的受试者比例均高于1993年。糖尿病的总体发病率为每年每1000人中有30.9例。在糖尿病发病病例中观察到更差的情况，其特征是与未患糖尿病者相比，人体测量和代谢变量的基线值更高。考虑人口统计学、营养和代谢变量以及身体活动水平对糖尿病发生的同时影响进行的分析表明，年龄、性别、腰围、空腹和2小时血浆葡萄糖浓度是独立的预测因素。
结论/解读：我们的数据表明日裔巴西人的葡萄糖耐量状况正在恶化，他们是全球糖尿病患病率最高的人群之一。这可能反映了他们与不利环境条件相关的强烈遗传易感性。
