Ayala Inmaculada, Baldassarre Massimiliano, Caldieri Giusi, Buccione Roberto
Tumor Cell Invasion Unit, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, I-66030 S. Maria Imbaro (Chieti), Italy.
Eur J Cell Biol. 2006 Apr;85(3-4):159-64. doi: 10.1016/j.ejcb.2005.09.005. Epub 2005 Oct 11.
The controlled degradation of extracellular matrix is crucial in physiological and pathological cell invasion alike. In cultured cells, degradation occurs at specific sites where invasive cells make contact with the extracellular matrix via specialized plasma membrane protrusions termed invadopodia. Considerable progress has been made in recent years towards understanding the basic molecular components and the ultrastructural features of invadopodia. This current knowledge will be reviewed here together with some of the most important open questions in invadopodia biology. Considering the substantial interest and momentum in the field, the need for an operational framework to correctly define and identify invadopodia will also be discussed.
细胞外基质的可控降解在生理和病理状态下的细胞侵袭过程中均至关重要。在培养细胞中，降解发生在特定部位，侵袭性细胞通过称为侵袭伪足的特殊质膜突起与细胞外基质接触。近年来，在理解侵袭伪足的基本分子成分和超微结构特征方面取得了相当大的进展。本文将回顾当前的这些知识，以及侵袭伪足生物学中一些最重要的未解决问题。鉴于该领域的浓厚兴趣和发展势头，还将讨论建立一个正确定义和识别侵袭伪足的操作框架的必要性。
