多核苷酸的抗病毒活性：肌苷酸与2-甲硫基肌苷酸的N2-二甲基鸟苷酸共聚物。
Antiviral activity of polynucleotides: copolymers of inosinic acid and N2-dimethylguanylic of 2-methylthioinosinic acid.
作者信息
De Clercq E, Hattori M, Ikehara M
出版信息
Nucleic Acids Res. 1975 Jan;2(1):121-9. doi: 10.1093/nar/2.1.121.
Complexes of poly(C) with copolymers of inosinic acid containing various amounts of mismatched bases (see journal for formula) have been examined for direct resistance to virus infection, interferon induction and toxicity in two different cell cultures (primary rabbit kidney cells and mouse L-929 cells). Complexes in which 20% of the hypoxanthine bases were replaced by (see journal for formula) or ms-2I were partially active whereas complexes in which 40% or more of the hypoxanthine bases were replaced by the odd bases were entirely inactive. The decrease in biological activity observed upon intrusion of (see journal for formula) or ms-2I in the poly(I) strand of poly(I) with poly(C) closely paralleled the amount of odd bases introduced irrespective of the system employed to assess the biological activity (resistance to virus infection, interferon induction or toxicity).
已对聚（C）与含有不同数量错配碱基的肌苷酸共聚物形成的复合物（化学式见期刊）在两种不同细胞培养物（原代兔肾细胞和小鼠L-929细胞）中进行了病毒感染直接抗性、干扰素诱导和毒性的检测。其中20%的次黄嘌呤碱基被（化学式见期刊）或ms-2I取代的复合物具有部分活性，而40%或更多次黄嘌呤碱基被这些奇碱基取代的复合物则完全无活性。在聚（I）与聚（C）形成的复合物中，当（化学式见期刊）或ms-2I插入聚（I）链时观察到的生物活性下降与引入的奇碱基数量密切相关，无论用于评估生物活性的系统（病毒感染抗性、干扰素诱导或毒性）如何。
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