细胞干扰素产生的调节：抗代谢物的增强作用。
Regulation of cellular interferon production: enhancement by antimetabolites.
作者信息
Tan Y H, Armstrong J A, Ke Y H, Ho M
出版信息
Proc Natl Acad Sci U S A. 1970 Sep;67(1):464-71. doi: 10.1073/pnas.67.1.464.
Abstract
Cycloheximide, at a protein-inhibitory concentration, when given to rabbit kidney cell cultures that had been exposed either to UV-irradiated Newcastle Disease virus or to a complex of polyinosinic and polycytidylic acids (poly I.poly C), enhanced the production of interferon. The enhancement was greater if, in addition to cycloheximide, the cells were also treated with actinomycin D. On the basis of these findings, a mechanism, consisting primarily of the production of a control protein which normally checks interferon production, is postulated for interferons stimulated by these two substances.
摘要
在蛋白质抑制浓度下，向已暴露于紫外线照射的新城疫病毒或聚肌苷酸和聚胞苷酸复合物（聚 I:聚 C）的兔肾细胞培养物中添加放线菌酮，可增强干扰素的产生。如果除放线菌酮外，细胞还接受放线菌素 D 处理，则增强作用会更大。基于这些发现，推测这两种物质刺激产生的干扰素的机制主要包括产生一种通常会抑制干扰素产生的控制蛋白。
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