聚（2-甲硫基肌苷酸）对肿瘤病毒功能的抑制作用
Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid).
作者信息
De Clercq E, Billiau A, Hattori M, Ikehara M
出版信息
Nucleic Acids Res. 1975 Dec;2(12):2305-13. doi: 10.1093/nar/2.12.2305.
Abstract
Poly (2-methylthioinosinic acid) [poly(ms2I)] was found to markedly inhibit the RNA directed DNA polymerase (reverse transcriptase) activity of murine (Moloney, Rauscher) leukemia virus and murine (Moloney) sarcoma virus, while under the same conditions the unsubstituted parent compound poly(I) showed little, if any, inhibitory effect. Copolymers of inosinic acid (I) and 2-methylthioinosinic acid2(ms2I) showed an intermediary effect, depending on the I:ms2I ratio. Poly(ms2I) also inhibited the transformation of normal cells by murine (Moloney) sarcoma virus, as assessed by an infectious center assay.
摘要
聚（2-甲硫基肌苷酸）[聚（ms2I）]被发现可显著抑制鼠（莫洛尼、劳舍尔）白血病病毒和鼠（莫洛尼）肉瘤病毒的RNA指导的DNA聚合酶（逆转录酶）活性，而在相同条件下，未取代的母体化合物聚（I）即使有抑制作用也很微弱。肌苷酸（I）和2-甲硫基肌苷酸2（ms2I）的共聚物表现出中间效应，这取决于I:ms2I的比例。通过感染中心试验评估，聚（ms2I）也抑制了鼠（莫洛尼）肉瘤病毒对正常细胞的转化。
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