Roy L, Gregoire E, Durand V, Buard V, Delbos M, Paillole N, Sorokine-Durm I, Gourmelon P, Voisin P
Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France.
Int J Radiat Biol. 2006 Jan;82(1):39-48. doi: 10.1080/09553000600579207.
To compare the efficiency of different cytogenetic tools in estimating the doses received by four people involved in the Lilo accident and to monitor the dose estimate over 4.5 years.
Several young Georgian frontier guards handled at least one of the 12 Caesium sources found in a former Russian military camp. Overexposure lasted from July 1996 to May 1997. The Institute for Radiological Protection and Nuclear Safety (IRSN) obtained blood samples taken at several intervals post-exposure from the four most highly-exposed people. Dose estimation was performed using dicentric and translocation scoring.
The first dose estimations performed by dicentric scoring gave whole-body doses ranging from 0.4 to 1.3 Gy. Overexposure was complex and several mathematical models were used to take this complexity into account. This could provide information concerning the circumstances of overexposure. Concerning follow-up, the yield of dicentrics decreased by about 50% in the first 4 months following the end of overexposure whereas translocations were stable over the period of analysis.
It has been useful to compare cytogenetic results with clinical results. The results presented here reveal good stability of translocations. However the first dose estimation was not attempted until 6 months after the last exposure.
比较不同细胞遗传学方法在估算利洛事故中四名受涉人员所接受剂量方面的效率，并在4.5年期间监测剂量估算情况。
几名年轻的格鲁吉亚边防警卫接触了在前俄罗斯军事营地发现的12个铯源中的至少一个。过度暴露从1996年7月持续到1997年5月。放射防护与核安全研究所（IRSN）获取了四名受照剂量最高人员在暴露后不同时间间隔采集的血样。使用双着丝粒和易位评分进行剂量估算。
首次通过双着丝粒评分进行的剂量估算得出全身剂量范围为0.4至1.3 Gy。过度暴露情况复杂，使用了几种数学模型来考虑这种复杂性。这可以提供有关过度暴露情况的信息。关于随访，在过度暴露结束后的前4个月，双着丝粒的产率下降了约50%，而易位在分析期间保持稳定。
将细胞遗传学结果与临床结果进行比较很有用。此处呈现的结果显示易位具有良好的稳定性。然而，直到最后一次暴露6个月后才进行首次剂量估算。
