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[体外循环后心脏衰竭的血流动力学方面。193例研究]

[Hemodynamic aspect of post ECC cardiac failures. Study of 193 cases].

作者信息

Diamant-Berger F, Haas C, Kieffer J P, Abry B, Hajjar R, Desnot F, Piwnica A, Dubost C

出版信息

Ann Anesthesiol Fr. 1977;18(1):81-93.

PMID:16547
Abstract

The aim of this study is to define the hemodynamic characteristics of this "clinical model" of acute cardiac failure observed after cardiac surgery carried out under extra-corporeal circulation, which constitutes the essential cause of "post-operative low cardiac output syndrome". The 193 patients in this study make up a representative sample of patients operated, treated and studied according to a homogeneous methodology for a period of 1 year. The clinical analysis of the post-operative circulatory condition, after exclusion of non cardiogenic syndromes, led to grouping the cases into 5 classes of circulatory change of increasing severity, each corresponding to a specific "therapeutic necessity". The hemodynamic results (intra-vascular pressures, oxymetry, cardiac output by "Cardio-Green" dilution method) are given for each of the five classes, thus defining the "hemodynamic profile" and the statistical reliability of the main objective parameters. This gives proof of the therapeutic indications for the main therapeutic procedures actually known, for which we prevent the hemodynamic effects noted for each of them. Thus, three "degrees of cardiac failure" are found: less severe (classes I and II) call for simple metabolic equilibration and possibly diuretics: the systolic work is above 160 gm/m2. Decompensated circulatory failure (classes III and IV) corresponds to a more important reduction in systolic work (9) 15 gm/m2, i.e. between 20 et 40 p. 100 of the basal value), and call for sympatho-mimetic cardiotonic agents: isoprenaline and/or dopamine. Below this value, in spite of medical treatment, the hemodynamic situation can still be sometimes reversible under circulatory assistance (diastolic counter pressure by means of an aortic balloon). Confronted with the clinical picture, the hemodynamic study enables the quantification of the circulatory change, and specification of the cardiogenic part and thus especially helps the carrying out of the treatment.

摘要

本研究的目的是确定在体外循环下进行心脏手术后观察到的这种急性心力衰竭“临床模型”的血流动力学特征,这是“术后低心排血量综合征”的主要原因。本研究中的193名患者构成了按照统一方法进行手术、治疗和研究达1年时间的患者的代表性样本。在排除非心源性综合征后,对术后循环状况进行临床分析,将病例分为5类循环变化,严重程度递增,每一类对应一种特定的“治疗需求”。给出了五类中每一类的血流动力学结果(血管内压力、血氧测定、用“心绿”稀释法测得的心排血量),从而确定了“血流动力学特征”以及主要客观参数的统计可靠性。这证明了目前已知的主要治疗方法的治疗指征,我们针对每一种方法预防其所观察到的血流动力学效应。因此,发现了三种“心力衰竭程度”:不太严重的(I类和II类)需要简单的代谢平衡,可能还需要利尿剂:收缩功高于160克/平方米。失代偿性循环衰竭(III类和IV类)对应于收缩功的更重要降低(9)15克/平方米,即基础值的20%至40%之间),需要拟交感神经强心剂:异丙肾上腺素和/或多巴胺。低于此值,尽管进行了药物治疗,在循环辅助(通过主动脉球囊产生舒张期反压)下血流动力学情况有时仍可能是可逆的。面对临床情况,血流动力学研究能够量化循环变化,并明确心源性部分,从而特别有助于进行治疗。

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