Bigl V, Arendt T
Paul Flechsig Institute for Brain Research, Department of Neurochemistry, Karl Marx University Leipzig, Federal Republic of Germany.
Acta Psychiatr Scand Suppl. 1991;366:7-13. doi: 10.1111/j.1600-0447.1991.tb03104.x.
Impairment of central cholinergic function is an early and constant finding in a number of mental disorders associated with amnesia or dementia. Although knowledge of the detailed functional implications of cholinergic mechanisms in cognition is still very incomplete, some recent results and concepts about the morphofunctional organization of the cholinergic basalo-cortical projection system are reviewed. This cholinergic system is quite different from other so-called unspecific subcortical projection systems and might have some bearing on understanding the role of cholinergic mechanisms in cognitive function and its disorders.
中枢胆碱能功能受损是许多与失忆或痴呆相关的精神障碍中早期且持续存在的表现。尽管目前关于胆碱能机制在认知中详细功能影响的认识仍很不完整，但本文综述了一些近期关于胆碱能基底 - 皮质投射系统形态功能组织的研究结果和概念。该胆碱能系统与其他所谓的非特异性皮质下投射系统有很大不同，可能有助于理解胆碱能机制在认知功能及其障碍中的作用。
