H1、H2和H3受体对人腺样体肥大细胞自发性组胺释放及刀豆蛋白A诱导的组胺释放的影响。
The influence of H1-, H2- and H3-receptors on the spontaneous and ConA induced histamine release from human adenoidal mast cells.
作者信息
Bent S, Fehling U, Braam U, Schunack W, Schmutzler W
机构信息
Institut für Pharmakologie und Toxikologie, Medizinische Fakultät der RWTH Aachen.
出版信息
Agents Actions. 1991 May;33(1-2):67-70. doi: 10.1007/BF01993129.
The effects of the H3-agonist R-alpha-methylhistamine (R-alpha-MeHA) and the H3-antagonist thioperamide on the spontaneous and concanavalin A (ConA) induced histamine release from human mast cells were tested and compared with the effect of some H1- and H2-receptor active substances. R-alpha-MeHA (10(-9)-10(-7) M) exerted no effect on histamine release whereas thioperamide increased the spontaneous release at 10(-6)-10(-4) M but inhibited the ConA induced release in a narrow concentration range (10(-6)-10(-5) M). This enhancement might be taken as an indication of the existence of H3-receptor dependent autoregulation although presently other mechanism cannot be excluded.
测试了H3激动剂R-α-甲基组胺（R-α-MeHA）和H3拮抗剂硫代酰胺对人肥大细胞自发释放和伴刀豆球蛋白A（ConA）诱导的组胺释放的影响，并与一些H1和H2受体活性物质的作用进行了比较。R-α-MeHA（10^(-9)-10^(-7) M）对组胺释放无影响，而硫代酰胺在10^(-6)-10^(-4) M时增加自发释放，但在狭窄浓度范围（10^(-6)-10^(-5) M）内抑制ConA诱导的释放。这种增强可能表明存在H3受体依赖性自调节，尽管目前不能排除其他机制。
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