人腺样体肥大细胞。对不同促分泌剂和分泌抑制剂的敏感性。

The human adenoidal mast cell. Susceptibility to different secretagogues and secretion inhibitors.

作者信息

Schmutzler W, Delmich K, Eichelberg D, Glück S, Greven T, Jürgensen H, Riesener K P, Risse G, Pult P

出版信息

Int Arch Allergy Appl Immunol. 1985;77(1-2):177-8. doi: 10.1159/000233778.

Abstract

Mast cells from adenoid tissues of man do not form a homogeneous population but differ in size and ultrastructure. They degranulate on stimulation with specific antigen, ionophore A 23187, Concanavalin A and, under certain conditions, antihuman IgE or acetylcholine. Compound 48/80, dextran, purified C3a or C5a are ineffective. Adenosine exerts either an enhancing or inhibiting effect on the stimulated histamine release, depending on the actual conditions of the mast cells. The study of a range of known mast cell degranulation inhibitors revealed important differences between human adenoidal mast cells and human basophils or animal mast cell systems. The efficacies of the drugs or drug combinations so far tested correspond well with the established therapeutic effects in man.

摘要

人腺样体组织中的肥大细胞并非同质群体，其大小和超微结构存在差异。它们在受到特异性抗原、离子载体A 23187、刀豆球蛋白A刺激时会脱颗粒，在某些条件下，抗人IgE或乙酰胆碱也能使其脱颗粒。化合物48/80、右旋糖酐、纯化的C3a或C5a则无效。腺苷对刺激引起的组胺释放要么有增强作用，要么有抑制作用，这取决于肥大细胞的实际状态。对一系列已知的肥大细胞脱颗粒抑制剂的研究揭示了人腺样体肥大细胞与人类嗜碱性粒细胞或动物肥大细胞系统之间的重要差异。迄今为止所测试的药物或药物组合的疗效与在人体中已确立的治疗效果相当吻合。