Jones P, Kortenkamp A, O'Brien P, Wang G, Yang G
Department of Chemistry, Queen Mary and Westfield College, University of London, United Kingdom.
Arch Biochem Biophys. 1991 May 1;286(2):652-5. doi: 10.1016/0003-9861(91)90095-z.
The formation of hydroxyl radicals from a chromium(V) complex isolated from the reaction of glutathione with chromate has been demonstrated in spin trapping experiments using dimethylsulfoxide and 3,5-dibromo-4-nitrosobenzene sulfonate. Mechanisms for the formation of radicals in such systems are discussed. These results help to explain the ability of solutions containing chromate and glutathione to cause strand breaks in DNA.
在使用二甲基亚砜和3,5-二溴-4-亚硝基苯磺酸盐的自旋捕获实验中，已证明从谷胱甘肽与铬酸盐反应中分离出的铬（V）络合物会形成羟基自由基。讨论了此类体系中自由基形成的机制。这些结果有助于解释含有铬酸盐和谷胱甘肽的溶液导致DNA链断裂的能力。
