顺磁性铬在六价铬诱导的培养哺乳动物细胞损伤中的作用。
Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
作者信息
Sugiyama M
机构信息
Department of Medical Biochemistry, Kurume University School of Medicine, Japan.
出版信息
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):31-3. doi: 10.1289/ehp.94102s331.
Chromium(VI) compounds are known to be potent toxic and carcinogenic agents. Because chromium(VI) is easily taken up by cells and is subsequently reduced to chromium(III), the formation of paramagnetic chromium such as chromium(V) and chromium(III) is believed to play a role in the adverse biological effects of chromium(VI) compounds. The present report, uses electron spin resonance (ESR) spectroscopy; the importance of the role of paramagnetic chromium in chromium(VI)-induced damage in intact cultured cells is discussed, based upon our studies with antioxidants including vitamin E (alpha-tocopherol), B2 (riboflavin), C (ascorbic acid), and so on. These studies appear to confirm the participation of paramagnetic Cr such as chromium(V) and Chromium(III) in chromium(VI)-induced cellular damage.
已知六价铬化合物是强效的有毒和致癌物质。由于六价铬很容易被细胞摄取并随后还原为三价铬，因此人们认为诸如五价铬和三价铬等顺磁性铬的形成在六价铬化合物的不良生物学效应中起作用。本报告使用电子自旋共振（ESR）光谱法；基于我们对包括维生素E（α-生育酚）、维生素B2（核黄素）、维生素C（抗坏血酸）等抗氧化剂的研究，讨论了顺磁性铬在完整培养细胞中六价铬诱导损伤中的作用的重要性。这些研究似乎证实了诸如五价铬和三价铬等顺磁性铬参与了六价铬诱导的细胞损伤。
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