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1
Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.顺磁性铬在六价铬诱导的培养哺乳动物细胞损伤中的作用。
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):31-3. doi: 10.1289/ehp.94102s331.
2
Role of physiological antioxidants in chromium(VI)-induced cellular injury.
Free Radic Biol Med. 1992;12(5):397-407. doi: 10.1016/0891-5849(92)90089-y.
3
Effects of vitamins on chromium(VI)-induced damage.维生素对六价铬诱导损伤的影响。
Environ Health Perspect. 1991 May;92:63-70. doi: 10.1289/ehp.919263.
4
Influence of vitamin B2 on formation of chromium(V), alkali-labile sites, and lethality of sodium chromate(VI) in Chinese hamster V-79 cells.维生素B2对中国仓鼠V-79细胞中铬（V）的形成、碱不稳定位点以及铬酸钠（VI）致死性的影响。
Cancer Res. 1989 Nov 15;49(22):6180-4.
5
Effect of ascorbic acid on DNA damage, cytotoxicity, glutathione reductase, and formation of paramagnetic chromium in Chinese hamster V-79 cells treated with sodium chromate(VI).抗坏血酸对用铬（VI）酸钠处理的中国仓鼠V - 79细胞中DNA损伤、细胞毒性、谷胱甘肽还原酶及顺磁性铬形成的影响。
J Biol Chem. 1991 Feb 25;266(6):3383-6.
6
In vivo reduction of chromium (VI) and its related free radical generation.体内六价铬的还原及其相关自由基的产生。
Mol Cell Biochem. 2001 Jun;222(1-2):41-7.
7
Chromium(VI) reduction by ascorbate: role of reactive intermediates in DNA damage in vitro.抗坏血酸盐对六价铬的还原作用：体外反应性中间体在DNA损伤中的作用
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):21-5. doi: 10.1289/ehp.94102s321.
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Time‑order effects of vitamin C on hexavalent chromium‑induced mitochondrial damage and DNA‑protein crosslinks in cultured rat peripheral blood lymphocytes.维生素 C 对六价铬诱导的培养大鼠外周血淋巴细胞线粒体损伤和 DNA-蛋白质交联的时间效应。
Mol Med Rep. 2013 Jul;8(1):53-60. doi: 10.3892/mmr.2013.1462. Epub 2013 May 8.
9
Pro-oxidative vs antioxidative properties of ascorbic acid in chromium(VI)-induced damage: an in vivo and in vitro approach.抗坏血酸在六价铬诱导损伤中的促氧化与抗氧化特性：体内和体外研究方法
J Appl Toxicol. 2005 Nov-Dec;25(6):535-48. doi: 10.1002/jat.1093.
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Formation of paramagnetic chromium in liver of mice treated with dichromate (VI).用重铬酸盐（VI）处理的小鼠肝脏中顺磁性铬的形成。
Toxicol Appl Pharmacol. 1995 Dec;135(2):165-71. doi: 10.1006/taap.1995.1219.

本文引用的文献

1
Influence of o-phenanthroline on DNA single-strand breaks, alkali-labile sites, glutathione reductase, and formation of chromium(V) in Chinese hamster V-79 cells treated with sodium chromate (VI).邻菲罗啉对用铬（VI）酸钠处理的中国仓鼠V-79细胞中DNA单链断裂、碱不稳定位点、谷胱甘肽还原酶及铬（V）形成的影响
Arch Biochem Biophys. 1993 Sep;305(2):261-6. doi: 10.1006/abbi.1993.1420.
2
DNA single-strand breaks and cytotoxicity induced by sodium chromate(VI) in hydrogen peroxide-resistant cell lines.铬（VI）酸钠在过氧化氢抗性细胞系中诱导的DNA单链断裂和细胞毒性。
Mutat Res. 1993 Apr;299(2):95-102. doi: 10.1016/0165-1218(93)90086-s.
3
Relatively long-lived chromium(V) species are produced by the action of glutathione on carcinogenic chromium(VI).谷胱甘肽作用于致癌性铬（VI）会产生寿命相对较长的铬（V）物种。
J Inorg Biochem. 1986 Mar;26(3):219-24. doi: 10.1016/0162-0134(86)80044-7.
4
Mechanism of DNA cleavage induced by sodium chromate(VI) in the presence of hydrogen peroxide.在过氧化氢存在下铬（VI）酸钠诱导DNA裂解的机制。
J Biol Chem. 1986 May 5;261(13):5952-8.
5
Generation of PM2 DNA breaks in the course of reduction of chromium(VI) by glutathione.谷胱甘肽还原六价铬过程中PM2 DNA断裂的产生。
Mutat Res. 1989 Feb;216(1):19-26. doi: 10.1016/0165-1161(89)90019-8.
6
On the mechanism of the chromate reduction by glutathione: ESR evidence for the glutathionyl radical and an isolable Cr(V) intermediate.关于谷胱甘肽还原铬酸盐的机制：谷胱甘肽自由基和可分离的Cr(V)中间体的电子顺磁共振证据。
Biochem Biophys Res Commun. 1988 Oct 14;156(1):137-42. doi: 10.1016/s0006-291x(88)80815-5.
7
Intracellular chromium reduction.
Biochim Biophys Acta. 1987 Oct 22;931(1):10-5. doi: 10.1016/0167-4889(87)90044-9.
8
Effect of vitamin E on survival, glutathione reductase and formation of chromium (V) in Chinese hamster V-79 cells treated with sodium chromate (VI).维生素E对经铬（VI）酸钠处理的中国仓鼠V - 79细胞的存活率、谷胱甘肽还原酶及铬（V）形成的影响。
Carcinogenesis. 1989 Apr;10(4):737-41. doi: 10.1093/carcin/10.4.737.
9
In vitro interaction of mutagenic chromium (VI) with red blood cells.
FEBS Lett. 1989 Oct 23;257(1):52-4. doi: 10.1016/0014-5793(89)81784-3.
10
Influence of vitamin B2 on formation of chromium(V), alkali-labile sites, and lethality of sodium chromate(VI) in Chinese hamster V-79 cells.维生素B2对中国仓鼠V-79细胞中铬（V）的形成、碱不稳定位点以及铬酸钠（VI）致死性的影响。
Cancer Res. 1989 Nov 15;49(22):6180-4.

顺磁性铬在六价铬诱导的培养哺乳动物细胞损伤中的作用。

Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.

作者信息

Sugiyama M

机构信息

Department of Medical Biochemistry, Kurume University School of Medicine, Japan.

出版信息

Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):31-3. doi: 10.1289/ehp.94102s331.

DOI:10.1289/ehp.94102s331
PMID:7843124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1567401/
Abstract

Chromium(VI) compounds are known to be potent toxic and carcinogenic agents. Because chromium(VI) is easily taken up by cells and is subsequently reduced to chromium(III), the formation of paramagnetic chromium such as chromium(V) and chromium(III) is believed to play a role in the adverse biological effects of chromium(VI) compounds. The present report, uses electron spin resonance (ESR) spectroscopy; the importance of the role of paramagnetic chromium in chromium(VI)-induced damage in intact cultured cells is discussed, based upon our studies with antioxidants including vitamin E (alpha-tocopherol), B2 (riboflavin), C (ascorbic acid), and so on. These studies appear to confirm the participation of paramagnetic Cr such as chromium(V) and Chromium(III) in chromium(VI)-induced cellular damage.

摘要

已知六价铬化合物是强效的有毒和致癌物质。由于六价铬很容易被细胞摄取并随后还原为三价铬，因此人们认为诸如五价铬和三价铬等顺磁性铬的形成在六价铬化合物的不良生物学效应中起作用。本报告使用电子自旋共振（ESR）光谱法；基于我们对包括维生素E（α-生育酚）、维生素B2（核黄素）、维生素C（抗坏血酸）等抗氧化剂的研究，讨论了顺磁性铬在完整培养细胞中六价铬诱导损伤中的作用的重要性。这些研究似乎证实了诸如五价铬和三价铬等顺磁性铬参与了六价铬诱导的细胞损伤。