Chou Kelvin L, Fernandez Hubert H
Department of Clinical Neurosciences, Brown Medical School, Providence, Rhode Island, USA.
Expert Opin Investig Drugs. 2006 Apr;15(4):339-49. doi: 10.1517/13543784.15.4.339.
Parkinson's disease (PD) patients commonly experience psychotic symptoms, with the most frequent manifestation being visual hallucinations. In PD, psychosis is predominantly drug induced and an important issue for clinicians to address as it increases the risk of nursing home placement as well as mortality. This review summarises the current knowledge regarding the clinical manifestations, pathophysiology and risk factors for drug-induced psychosis in patients with PD and focuses on treatment, especially with regard to the atypical antipsychotics.
帕金森病（PD）患者常出现精神症状，最常见的表现是视幻觉。在帕金森病中，精神病主要由药物诱发，这是临床医生需要解决的一个重要问题，因为它会增加患者入住疗养院的风险以及死亡率。本综述总结了目前关于帕金森病患者药物性精神病的临床表现、病理生理学和危险因素的知识，并着重于治疗，尤其是非典型抗精神病药物的治疗。
