对黑素细胞刺激素介导的生长抑制具有抗性的黑色素瘤细胞。
Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone.
作者信息
Pawelek J, Sansone M, Koch N, Christie G, Halaban R, Hendee J, Lerner A B, Varga J M
出版信息
Proc Natl Acad Sci U S A. 1975 Mar;72(3):951-5. doi: 10.1073/pnas.72.3.951.
Melanocyte stimulating hormone (MSH) enhances melanization but inhibits proliferation of Cloudman S91 melanoma cells in culture. We have isolated variants of these cells that can grow in the presence of MSH. The conclusions we have reached from analyses of these cells are the following: (1) Basal tyrosinase activity (monophenol monooxygenase; monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1), i.e., the activity that is present in the absence of added MSH, is related through a common biochemical pathway to MSH-mediated control of growth. (2) MSH-inducible tyrosinase activity does not appear to be related to MSH control of growth. (3) The morphological changes that occur following the addition of MSH or cAMP are related to controls of growth and not to those of melanization.
促黑素细胞激素（MSH）可增强黑色素生成，但在培养中会抑制Cloudman S91黑色素瘤细胞的增殖。我们已经分离出了这些细胞的变体，它们能够在MSH存在的情况下生长。我们对这些细胞进行分析后得出以下结论：（1）基础酪氨酸酶活性（单酚单加氧酶；单酚，二羟基苯丙氨酸：氧氧化还原酶，EC 1.14.18.1），即在不添加MSH时存在的活性，通过一条共同的生化途径与MSH介导的生长控制相关。（2）MSH诱导的酪氨酸酶活性似乎与MSH对生长的控制无关。（3）添加MSH或cAMP后发生的形态变化与生长控制有关，而与黑色素生成控制无关。
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