Virus-specific CD4+ T cells: ready for direct attack.
作者信息
Heller Kevin N, Gurer Cagan, Münz Christian
机构信息
Laboratory of Viral Immunobiology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA.
出版信息
J Exp Med. 2006 Apr 17;203(4):805-8. doi: 10.1084/jem.20060215. Epub 2006 Mar 20.
Abstract
CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4+ T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4+ T cells.
摘要
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