Rowe I F
Highfield Hospital, Droitwich, UK.
Curr Opin Rheumatol. 1991 Aug;3(4):621-7. doi: 10.1097/00002281-199108000-00012.
Musculoskeletal conditions occurring in individuals with human immunodeficiency virus infection are becoming increasingly well documented. Arthritis with features of Reiter's syndrome or psoriatic arthritis has been further studied; an association with HLA-B27 but not with HLA antigens chemically associated with psoriasis or psoriatic arthritis has been demonstrated. Human immunodeficiency virus has been identified in synovial fluid dendritic cells and in the synovium; immunohistochemical analysis is revealing the nature of the lymphocyte infiltrate in the synovium of affected individuals. Postmortem studies suggest that there may be histologic evidence of premature aging in clinically unaffected joints from patients with acquired immunodeficiency syndrome. Epidemiologic studies are needed to elucidate which rheumatic lesions occur as a direct consequence of human immunodeficiency infection and which may be chance associations.
人类免疫缺陷病毒感染个体中出现的肌肉骨骼疾病越来越多地得到了充分记录。具有赖特综合征或银屑病关节炎特征的关节炎得到了进一步研究；已证明其与HLA - B27相关，但与化学上与银屑病或银屑病关节炎相关的HLA抗原无关。在滑液树突状细胞和滑膜中已鉴定出人类免疫缺陷病毒；免疫组织化学分析正在揭示受影响个体滑膜中淋巴细胞浸润的性质。尸检研究表明，获得性免疫缺陷综合征患者临床上未受影响的关节可能存在过早老化的组织学证据。需要进行流行病学研究，以阐明哪些风湿性病变是人类免疫缺陷病毒感染的直接后果，哪些可能是偶然关联。
