（+）-CC-1065会使DNA发生弯曲，这种弯曲似乎类似于腺嘌呤/胸腺嘧啶序列。 - Suppr

Suppr

超能文献

(+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts.

作者信息

Lin C H, Sun D Y, Hurley L H

机构信息

Drug Dynamics Institute, College of Pharmacy, Austin, Texas.

出版信息

Chem Res Toxicol. 1991 Jan-Feb;4(1):21-6. doi: 10.1021/tx00019a003.

DOI:10.1021/tx00019a003

PMID:1655087

Abstract

摘要

相似文献

(+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts.（+）-CC-1065会使DNA发生弯曲，这种弯曲似乎类似于腺嘌呤/胸腺嘧啶序列。

Chem Res Toxicol. 1991 Jan-Feb;4(1):21-6. doi: 10.1021/tx00019a003.

A-tract and (+)-CC-1065-induced bending of DNA. Comparison of structural features using non-denaturing gel analysis, hydroxyl-radical footprinting, and high-field NMR.A-序列和（+）-CC-1065诱导的DNA弯曲。使用非变性凝胶分析、羟基自由基足迹法和高场核磁共振对结构特征进行比较。

Biochemistry. 1993 May 4;32(17):4487-95. doi: 10.1021/bi00068a003.

DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065.DNA链间交联、DNA序列特异性以及由（+）-CC-1065的二聚体类似物产生的诱导构象变化。

Anticancer Drug Des. 1991 Nov;6(5):427-52.

Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA.确定负责使DNA弯曲和缠绕的（+）-CC-1065的结构特征。

Chem Res Toxicol. 1991 Mar-Apr;4(2):203-13. doi: 10.1021/tx00020a013.

(+)-CC-1065 as a probe for intrinsic and protein-induced bending of DNA.（+）-CC-1065作为DNA固有弯曲和蛋白质诱导弯曲的探针。

J Mol Recognit. 1994 Jun;7(2):123-32. doi: 10.1002/jmr.300070209.

The minor groove covalent reactive drugs anthramycin and (+)-CC-1065 and their interstrand cross-linking derivatives.小沟共价反应性药物安丝菌素和（+）-CC-1065及其链间交联衍生物。

IARC Sci Publ. 1994(125):295-312.

An NMR study of the covalent and noncovalent interactions of CC-1065 and DNA.CC-1065与DNA的共价和非共价相互作用的核磁共振研究。

Biochemistry. 1990 Mar 20;29(11):2852-60. doi: 10.1021/bi00463a031.

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity.(+)-和对映体(-)-CC-1065及相关试剂对序列选择性DNA烷基化的分子基础：适应富含腺嘌呤的富AT序列偏移的腺嘌呤N3烷基化选择性的烷基化位点模型。

Bioorg Med Chem. 1994 Feb;2(2):115-35. doi: 10.1016/s0968-0896(00)82007-6.

Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies.通过¹H和¹⁵N核磁共振研究确定（+）-CC-1065-DNA加合物中经共价修饰的腺嘌呤的主要互变异构形式。

Biochemistry. 1990 Oct 16;29(41):9503-7. doi: 10.1021/bi00493a002.

DNA sequence recognition by the antitumor antibiotic CC-1065 and analogs of CC-1065.

Chem Biol Interact. 1991;79(3):265-86. doi: 10.1016/0009-2797(91)90109-k.

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(+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprinting.

Nucleic Acids Res. 1993 Sep 11;21(18):4281-7. doi: 10.1093/nar/21.18.4281.

Stereochemistry-dependent bending in oligonucleotide duplexes induced by site-specific covalent benzo[a]pyrene diol epoxide-guanine lesions.位点特异性共价苯并[a]芘二醇环氧化物-鸟嘌呤损伤诱导的寡核苷酸双链体中的立体化学依赖性弯曲

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