延迟性AMPA受体阻断可减轻局灶性缺血所致的脑梗死。

Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia.

作者信息

Buchan A M, Xue D, Huang Z G, Smith K H, Lesiuk H

机构信息

Division of Neurology and Neuroscience, Ottawa Civic Hospital, Ontario, Canada.

出版信息

Neuroreport. 1991 Aug;2(8):473-6. doi: 10.1097/00001756-199108000-00016.

DOI:10.1097/00001756-199108000-00016

PMID:1655110

Abstract

The potent and selective AMPA receptor antagonist NBQX was tested for cytoprotective properties in an adult rat model of transient focal neocortical ischemia. Nineteen spontaneously hypertensive rats sustained 2 h of middle cerebral artery occlusion, followed by 22 h of recirculation. Ninety minutes following the onset of ischemia, at the time of, and 30 min following reperfusion, they received i.p. injections of either saline (n = 10) or 30 mg kg-1 of NBQX (n = 9). Saline-treated rats had a mean volume of neocortical infarction ( +/- s.d.) of 181 +/- 31 mm3, while NBQX-treated rats sustained significantly less damage, 125 +/- 19 mm3 (p less than 0.001). Regional cerebral blood flows during ischemia and reperfusion were not affected by the drug. We suggest that the AMPA receptor may play an important role in ischemic cerebral infarction.

摘要

在成年大鼠短暂性局灶性新皮质缺血模型中，对强效且具选择性的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体拮抗剂NBQX的细胞保护特性进行了测试。19只自发性高血压大鼠经历了2小时的大脑中动脉闭塞，随后进行22小时的再灌注。在缺血开始后90分钟、缺血时以及再灌注后30分钟，它们接受腹腔注射生理盐水（n = 10）或30毫克/千克的NBQX（n = 9）。生理盐水处理的大鼠新皮质梗死平均体积（±标准差）为181±31立方毫米，而NBQX处理的大鼠损伤明显较小，为125±19立方毫米（p<0.001）。缺血和再灌注期间的局部脑血流量不受该药物影响。我们认为AMPA受体可能在缺血性脑梗死中起重要作用。