Pekala J S, Gururangan S, Provenzale J M, Mukundan S
Department of Radiology and The Brain Tumor Center at Duke, Durham, NC, USA.
AJNR Am J Neuroradiol. 2006 Mar;27(3):580-3.
Although these entities are histologically similar, recent advances in molecular genetics have allowed the distinction of central nervous system extraosseous Ewing sarcoma (CNS-EES) from central primitive neuroectodermal tumors (c-PNET) including medulloblastoma and supratentorial PNET. We present 2 cases of pathologically confirmed CNS-EES. Knowledge of CNS-EES as a distinct entity enables the neuroradiologist to suggest the proper diagnosis and the need for special immuno-histochemical and molecular studies to confirm the diagnosis. Because treatment and prognosis are vastly different, the proper diagnosis of CNS-EES versus c-PNET is critical.
尽管这些实体在组织学上相似，但分子遗传学的最新进展已使中枢神经系统骨外尤文肉瘤（CNS-EES）能够与包括髓母细胞瘤和幕上原始神经外胚层肿瘤（c-PNET）在内的中枢原始神经外胚层肿瘤区分开来。我们报告2例经病理证实的CNS-EES病例。将CNS-EES视为一种独特的实体，有助于神经放射科医生做出正确的诊断，并提示需要进行特殊的免疫组织化学和分子研究以确诊。由于治疗方法和预后差异很大，正确区分CNS-EES和c-PNET至关重要。
