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Clinical Features and Long-Term Outcome of Primary Intracranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors: 14 Cases From a Single Institution.原发性颅内尤因肉瘤/外周原始神经外胚层肿瘤的临床特征及长期预后：来自单一机构的14例病例
World Neurosurg. 2019 Feb;122:e1606-e1614. doi: 10.1016/j.wneu.2018.11.151. Epub 2018 Nov 26.
2
Primary Intracranial pPNET/Ewing Sarcoma: Diagnosis, Management, and Prognostic Factors Dilemma-A Systematic Review of the Literature.原发性颅内原始神经外胚层肿瘤/尤因肉瘤：诊断、治疗及预后因素困境——文献系统综述
World Neurosurg. 2018 Jul;115:346-356. doi: 10.1016/j.wneu.2018.04.164. Epub 2018 May 3.
3
Extraosseous Primary Intracranial Ewing Sarcoma/peripheral Primitive Neuroectodermal Tumor: Series of Seven Cases and Review of Literature.骨外原发性颅内尤文肉瘤/外周原始神经外胚层肿瘤：7例病例系列及文献复习
Asian J Neurosurg. 2018 Apr-Jun;13(2):288-296. doi: 10.4103/1793-5482.228570.
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Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding.原发性枕部尤因肉瘤伴随后期脊柱播散。
Case Rep Pediatr. 2017;2017:1521407. doi: 10.1155/2017/1521407. Epub 2017 Jun 13.
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Primary intracranial Ewing sarcoma with an unusually aggressive course: a case report and review of the literature.原发性颅内尤文肉瘤：一种侵袭性很强的疾病——病例报告及文献复习
Neuropathology. 2012 Jun;32(3):293-300. doi: 10.1111/j.1440-1789.2011.01258.x. Epub 2011 Oct 18.
6
The 2007 WHO classification of tumours of the central nervous system.2007年世界卫生组织中枢神经系统肿瘤分类
Acta Neuropathol. 2007 Aug;114(2):97-109. doi: 10.1007/s00401-007-0243-4. Epub 2007 Jul 6.
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Peripheral primitive neuroectodermal tumor/Ewing's sarcoma of the craniospinal vault: case reports and review.颅脊柱穹窿部外周原始神经外胚层肿瘤/尤因肉瘤：病例报告及文献复习
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8
Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial.在欧洲EWING 99临床试验中，长春新碱、异环磷酰胺、阿霉素和依托泊苷（VIDE）强化诱导治疗尤文氏肿瘤的安全性评估
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Adult medulloblastoma: multiagent chemotherapy.成人髓母细胞瘤：多药化疗
Neuro Oncol. 2001 Jan;3(1):29-34. doi: 10.1093/neuonc/3.1.29.

原发性颅内尤因肉瘤的最佳治疗方法。

Optimum treatment for primary intracranial Ewing sarcoma.

作者信息

Howell Sasha G, Lyon Kristopher A, Garrett David, Huang Jason H, Fonkem Ekokobe

机构信息

Department of Neurosurgery, Baylor Scott & White Medical CenterTempleTexas.

Department of Surgery, Texas A&M University College of MedicineTempleTexas.

出版信息

Proc (Bayl Univ Med Cent). 2020 May 4;33(3):430-432. doi: 10.1080/08998280.2020.1755199. eCollection 2020 Jul.

DOI:10.1080/08998280.2020.1755199
PMID:32675975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7340410/
Abstract

Ewing sarcoma (ES) is an aggressive, high-grade neuroectodermal neoplasm that frequently manifests in children and young adults. Although ES without osseous involvement most commonly involves paravertebral regions of the spine, it very rarely presents as a primary intracranial tumor. This report discusses a unique presentation of an adult extraosseous ES arising from the pineal region with extension into the third and fourth ventricles and multiple drop metastases to the spine. This case demonstrates the application of current chemotherapeutic and adjuvant management and offers insight into possible treatment modalities for metastasis in an atypical extraosseous ES involving the brain and spine.

摘要

尤因肉瘤（ES）是一种侵袭性的高级别神经外胚层肿瘤，常见于儿童和青年。虽然无骨受累的ES最常累及脊柱的椎旁区域，但它极少表现为原发性颅内肿瘤。本报告讨论了一例成人松果体区骨外ES的独特表现，肿瘤延伸至第三和第四脑室，并向脊柱多发播散转移。该病例展示了当前化疗和辅助治疗的应用，并为涉及脑和脊柱的非典型骨外ES转移的可能治疗方式提供了见解。