骨髓扩散测量结果与HIV患者的痴呆严重程度相关。
Bone marrow diffusion measures correlate with dementia severity in HIV patients.
作者信息
Ragin A B, Wu Y, Storey P, Cohen B A, Edelman R R, Epstein L G, Gartner S
机构信息
Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA.
出版信息
AJNR Am J Neuroradiol. 2006 Mar;27(3):589-92.
BACKGROUND AND PURPOSE
Escalation in monocyte trafficking from the bone marrow into the brain may play a critical role in central nervous system injury and cognitive deterioration in patients with HIV infection. This study tested the hypothesis that the mean diffusivity is sensitive to marrow changes in HIV patients and that these quantitative imaging measurements correlate with the severity of dementia.
METHODS
The mean diffusivity (MD), determined for clival and calvarial marrow regions, was compared in 11 HIV-infected patients and 9 control subjects. The imaging measurements were also evaluated for relationships with dementia severity and markers of disease progression (CD4 and viral load in plasma).
RESULTS
The MD was significantly reduced in both clival and calvarial marrow in HIV-infected patients (P =.006). Diffusion measurements for clival (P =.02) and for calvarial (P =.03) regions were significantly correlated with the severity of dementia.
CONCLUSION
The results of this investigation support the utility of diffusion strategies for monitoring the marrow and provide further evidence of a relationship between marrow status changes and neurologic progression in HIV patients.
背景与目的
从骨髓向大脑的单核细胞运输增加可能在HIV感染患者的中枢神经系统损伤和认知衰退中起关键作用。本研究检验了以下假设：平均扩散率对HIV患者的骨髓变化敏感，且这些定量成像测量值与痴呆严重程度相关。
方法
比较了11例HIV感染患者和9例对照受试者斜坡和颅骨骨髓区域的平均扩散率（MD）。还评估了成像测量值与痴呆严重程度及疾病进展标志物（血浆CD4和病毒载量）之间的关系。
结果
HIV感染患者的斜坡和颅骨骨髓MD均显著降低（P = 0.006）。斜坡区域（P = 0.02）和颅骨区域（P = 0.03）的扩散测量值与痴呆严重程度显著相关。
结论
本研究结果支持扩散策略在监测骨髓方面的实用性，并进一步证明了HIV患者骨髓状态变化与神经病变进展之间的关系。
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