Puig Oscar, Tjian Robert
Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Cell Cycle. 2006 Mar;5(5):503-5. doi: 10.4161/cc.5.5.2501. Epub 2006 Mar 1.
Organisms adjust their rate of growth depending on the availability of nutrients. Thus, when environmental conditions limit nutrients, growth is slowed and is only restored after food again becomes abundant. Many aspects of the molecular mechanisms that govern this complex control system remain unknown. However, it has been shown that the insulin/IGF-1 (insulin-like growth factor 1) receptor pathway, together with the FOXO family of transcription factors, play an important role in this process. Recent studies with the fruit fly Drosophila melanogaster have provided new insights into the regulatory circuitry that controls both growth and gene expression in response to nutrient availability.
生物体根据营养物质的可获得性来调整其生长速率。因此，当环境条件限制营养物质时，生长会减缓，只有在食物再次变得充足后才会恢复。控制这个复杂控制系统的分子机制的许多方面仍然未知。然而，已经表明胰岛素/IGF-1（胰岛素样生长因子1）受体途径与FOXO转录因子家族在这个过程中起重要作用。最近对果蝇黑腹果蝇的研究为响应营养物质可获得性而控制生长和基因表达的调节电路提供了新的见解。
