Van Dross Rukiyah, Browning Philip J, Pelling Jill C
Department of Pharmacology and Toxicology, Leo Jenkins Cancer Center, East Carolina University, Greenville, North Carolina 27834, USA.
Cell Cycle. 2006 Mar;5(5):472-7. doi: 10.4161/cc.5.5.2516. Epub 2006 Mar 1.
Cyclin overexpression is found in several types of cancer. Genetic events that place cyclin genes under the control of active promoters or that increase cyclin gene copy number account for most instances of cyclin overexpression. New paradigms for aberrant cyclin expression have been suggested by studies showing that truncated cyclins are expressed in specific subsets of cancer. The altered cyclins lack regulatory sequences (compared to the wild-type protein) that modulate their stability, subcellular localization or cdk-associated kinase activity. In this communication, we review the current literature and assess the role of truncated cyclins D, E, A, B, C and virus encoded-cyclin D (K-cyclin) in the development of cancer. We also report the molecular characteristics, expression patterns and if available, prognostic significance of these proteins.
在多种类型的癌症中均发现细胞周期蛋白过表达。使细胞周期蛋白基因受活性启动子控制或增加细胞周期蛋白基因拷贝数的遗传事件是细胞周期蛋白过表达的主要原因。研究表明，截短的细胞周期蛋白在特定的癌症亚群中表达，由此提出了异常细胞周期蛋白表达的新范式。与野生型蛋白相比，这些改变的细胞周期蛋白缺乏调节其稳定性、亚细胞定位或与细胞周期蛋白依赖性激酶相关的激酶活性的调控序列。在本通讯中，我们综述了当前的文献，并评估了截短的细胞周期蛋白D、E、A、B、C以及病毒编码的细胞周期蛋白D（K-细胞周期蛋白）在癌症发生发展中的作用。我们还报告了这些蛋白的分子特征、表达模式以及（如有的话）预后意义。
