4th Department of Surgery, Medical School, University of Athens, Attikon General Hospital, Athens, Greece.
World J Surg Oncol. 2010 Dec 22;8:111. doi: 10.1186/1477-7819-8-111.
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy.
细胞周期蛋白是细胞周期不可缺少的组成部分，其功能失调可导致癌症的形成。最近的研究还揭示了细胞周期蛋白发挥致癌潜能的更多机制。这篇综述重点介绍了 G1/S 细胞周期蛋白，尤其是细胞周期蛋白 D 和 E 的异常表达；它们导致肿瘤形成的途径及其在不同类型癌症中的参与。这些因素表明了可能作为癌症治疗靶点的机制。
