欧洲女性的体重指数、腰围、腰臀比以及胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的血清水平

Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women.

作者信息

Gram I T, Norat T, Rinaldi S, Dossus L, Lukanova A, Téhard B, Clavel-Chapelon F, van Gils C H, van Noord P A H, Peeters P H M, Bueno-de-Mesquita H B, Nagel G, Linseisen J, Lahmann P H, Boeing H, Palli D, Sacerdote C, Panico S, Tumino R, Sieri S, Dorronsoro M, Quirós J R, Navarro C A, Barricarte A, Tormo M-J, González C A, Overvad K, Paaske Johnsen S, Olsen A, Tjønneland A, Travis R, Allen N, Bingham S, Khaw K-T, Stattin P, Trichopoulou A, Kalapothaki V, Psaltopoulou T, Casagrande C, Riboli E, Kaaks R

机构信息

Institute of Community Medicine, School of Medicine, University of Tromsø, Tromsø, Norway.

出版信息

Int J Obes (Lond). 2006 Nov;30(11):1623-31. doi: 10.1038/sj.ijo.0803324. Epub 2006 Mar 21.

DOI:10.1038/sj.ijo.0803324

PMID:16552400

Abstract

OBJECTIVE

To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulin-like growth factor-I (IGF-I), and its binding protein (IGFBP)-3.

DESIGN

Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3.

RESULTS

Adjusted mean serum IGF-I values were lower in women with BMI<22.5 kg/m(2) or BMI>29.2 kg/m(2) compared to women with BMI within this range (P(heterogeneity)<0.0001, P(trend)=0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (P (trend)=0.005).

CONCLUSIONS

Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to non-obese women and inversely related to central adiposity.

摘要

目的

研究体重指数（BMI）和腰臀比（WHR）与血清胰岛素样生长因子-I（IGF-I）及其结合蛋白（IGFBP）-3水平之间的关系。

设计

对2139名参与乳腺癌与内源性激素病例对照研究的女性进行横断面研究。通过问卷调查收集生活方式和生殖因素的数据。测量身高、体重、腰围和臀围。采用酶联免疫吸附测定法测量血清IGF-I和胰岛素样结合蛋白（IGFBP）-3水平。通过线性回归计算BMI、腰围和WHR五分位数组中IGF-I和IGFBP-3的校正平均水平。对与IGF-I和IGFBP-3相关的潜在混杂因素进行结果校正。

结果

与BMI在此范围内的女性相比，BMI<22.5 kg/m²或BMI>29.2 kg/m²的女性校正后血清IGF-I平均水平较低（P（异质性）<0.0001，P（趋势）=0.35）。校正BMI后，胰岛素样生长因子-I与WHR无关。相互校正后，IGF结合蛋白-3与腰围和WHR呈线性正相关。IGF-I/IGFBP-3摩尔比与BMI呈非线性关系，与WHR呈线性负相关（P（趋势）=0.005）。