血清 IGF-1 与 BMI 的关系随年龄而变化。
Relationship Between Serum IGF-1 and BMI Differs by Age.
机构信息
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
出版信息
J Gerontol A Biol Sci Med Sci. 2021 Jun 14;76(7):1303-1308. doi: 10.1093/gerona/glaa282.
BACKGROUND
Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies.
METHODS
Using data on 4241 participants (aged 24-110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis.
RESULTS
When stratified by age quartile, the relationship between IGF-1 and BMI varied: in the first quartile (Q1, 20-58 years) the relationship was negative (β = -0.2, p = .002); in Q2 (58-66 years) and Q3 (67-86 years) the relationship was negative (β = -0.07, β = -0.01, respectively) but nonsignificant; and in Q4 (87-110 years) the relationship was positive (β = 0.31, p = .0002). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey.
CONCLUSIONS
Our results that the relationship between IGF-1 and BMI differs by age may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.
背景
胰岛素样生长因子 1（IGF-1）血清水平和体重指数（BMI）均与与年龄相关疾病的易感性相关。关于它们之间相关性的报告相互矛盾，既有正相关也有负相关的报道。然而，这些研究中参与者的年龄范围差异很大。
方法
使用来自长寿家族研究的 4241 名参与者（年龄 24-110 岁）的数据，我们通过回归分析按年龄组研究 IGF-1 与 BMI 之间的关系。
结果
按年龄四分位(Q1，20-58 岁)分层时，IGF-1 与 BMI 的关系不同：在 Q1 中呈负相关（β = -0.2，p =.002）；在 Q2（58-66 岁）和 Q3（67-86 岁）中呈负相关（β = -0.07，β = -0.01），但无统计学意义；在 Q4（87-110 岁）中呈正相关（β = 0.31，p =.0002）。这种模式在性别之间没有差异。我们在第三次国家健康和营养检查调查的参与者中观察到 IGF-1 和 BMI 之间存在类似的与年龄相关的模式。
结论
我们的研究结果表明，IGF-1 与 BMI 之间的关系因年龄而异，这可能解释了它们之间关系报告的一些不一致，并鼓励进一步研究以了解其潜在机制。
Zotero 插件