Piatak O A, Yanovskii G V, Lizogub V G
Chair of Therapy, Paediatric Faculty, Kiev Medical Institute, USSR.
Cor Vasa. 1991;33(1):19-25.
The influence of anaprilin, oxprenolol, nonachlazine, prazosin and levodopa on the clinical course and haemodynamics was investigated in 138 patients with ischaemic heart disease in whom selective coronary angiography had revealed an up to 50 percent stenosis of one of coronary arteries. The clinical picture of IHD patients with a high tolerance of physical exercise was characterized by a preponderance of spontaneous angina pectoris accompanied by painless myocardial ischaemia. A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity. Prazosin and nonachlazine in monotherapy reduced the number of anginal attacks and episodes of painless myocardial ischaemia.
对138例缺血性心脏病患者进行了研究，这些患者经选择性冠状动脉造影显示某一支冠状动脉狭窄达50%，研究了心得安、氧烯洛尔、苄氯嗪、哌唑嗪和左旋多巴对其临床病程及血流动力学的影响。体力活动耐受性高的缺血性心脏病患者的临床表现特点为以自发性心绞痛为主，并伴有无痛性心肌缺血。α1肾上腺素能受体活性相对增加及β肾上腺素能受体活性降低在这些紊乱的发生中起一定作用。哌唑嗪和苄氯嗪单一疗法可减少心绞痛发作次数及无痛性心肌缺血发作次数。
