Zaslavskaia R M, Zolotaia R D, Olevskiĭ I Kh, Duda S G, Vilkovyskiĭ F A
Farmakol Toksikol. 1986 Nov-Dec;49(6):73-7.
During course therapy with nonachlazine of patients with ischemic heart disease, stable angina pectoris a negative inotropic effect of the drug in persons with eukinetic and in particular hyperkinetic type of hemodynamics was revealed. Enhancement of beta-adrenoblocking effect of nonachlazine with an increase of its daily dose was found. Nonachlazine effect on hemodynamic parameters was shown to be mediated through adrenoreactive structures.
在对缺血性心脏病、稳定型心绞痛患者进行非那嗪疗程治疗期间，发现该药物对具有正常动力型尤其是高动力型血流动力学的患者有负性肌力作用。随着非那嗪日剂量增加，其β-肾上腺素能阻滞作用增强。结果表明，非那嗪对血流动力学参数的影响是通过肾上腺素反应性结构介导的。
