Thyagarajan Bharat, Jacobs David R, Apostol George G, Smith Lewis J, Lewis Cora E, Williams O Dale
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454, USA.
Int J Epidemiol. 2006 Aug;35(4):1001-8. doi: 10.1093/ije/dyl049. Epub 2006 Mar 22.
We hypothesized that fibrinogen, as a marker of chronic inflammation, is inversely associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) in healthy persons.
The CARDIA cohort started in 1985 and included black and white men and women, aged 18-30, from the general population. Spirometry testing conducted at years 5 and 10 [FVC, FEV(1), and their ratio (FEV(1)/FVC)] was studied relative to plasma fibrinogen levels measured at year 5 (cross-sectional n = 4,040) and at year 7 (longitudinal n = 3,001), controlling for race, sex, age, height, smoking, asthma, body mass index, physical activity, birth control pill use, and alcohol intake.
In cross-sectional analyses, FVC at year 5 was lower by 166 ml (95% confidence interval 116-216 ml) in the highest vs lowest year 5 fibrinogen quartile. At year 10, holding year 5 FVC and change in fibrinogen (year 7-year 5) constant, the difference in FVC between the highest and the lowest year 5 fibrinogen quartiles widened by 67 ml (95% CI 31-103 ml). The corresponding differences for FEV(1) were 166 ml (95% CI 146-253 ml) at year 5 and 45 ml (95% CI 11-80 ml) widening by year 10. The FEV(1)/FVC ratio was unrelated to plasma fibrinogen.
These findings are consistent with the hypothesis that fibrinogen, possibly as a marker for chronic low-grade inflammation, is associated with modest deterioration of lung function in healthy young adults.
我们推测，作为慢性炎症标志物的纤维蛋白原与健康人的用力肺活量（FVC）和1秒用力呼气量（FEV₁）呈负相关。
CARDIA队列研究始于1985年，纳入了来自普通人群的18 - 30岁的黑人和白人男性及女性。研究了在第5年和第10年进行的肺量计测试[FVC、FEV₁及其比值（FEV₁/FVC）]与在第5年（横断面研究n = 4040）和第7年（纵向研究n = 3001）测量的血浆纤维蛋白原水平的关系，同时控制种族、性别、年龄、身高、吸烟、哮喘、体重指数、体力活动、避孕药使用和酒精摄入量。
在横断面分析中，第5年纤维蛋白原四分位数最高组与最低组相比，第5年的FVC降低了166毫升（95%置信区间116 - 216毫升）。在第10年，保持第5年的FVC和纤维蛋白原变化（第7年 - 第5年）不变，第5年纤维蛋白原四分位数最高组与最低组之间的FVC差异扩大了67毫升（95%置信区间31 - 103毫升）。FEV₁的相应差异在第5年为166毫升（95%置信区间146 - 253毫升），到第10年扩大了45毫升（95%置信区间11 - 80毫升）。FEV₁/FVC比值与血浆纤维蛋白原无关。
这些发现与以下假设一致，即纤维蛋白原可能作为慢性低度炎症的标志物，与健康年轻成年人的肺功能适度恶化有关。
