Neumann D A, Lane J R, LaFond-Walker A, Allen G S, Frondoza C, Herskowitz A, Rose N R
Johns Hopkins University, School of Hygiene and Public Health, Department of Immunology and Infectious Diseases, Baltimore, Maryland 21205.
Eur Heart J. 1991 Aug;12 Suppl D:113-6. doi: 10.1093/eurheartj/12.suppl_d.113.
Circulating heart-reactive antibodies are commonly reported in myocarditis and cardiomyopathy patients. While these observations support the hypothesis that autoimmune mechanisms may be involved in pathogenesis, such evidence is largely circumstantial. The current studies demonstrate that heart-reactive antibodies can be eluted from the hearts of infected Coxsackievirus B3-infected A/J mice with post-infectious autoimmune myocarditis, but not from the hearts of infected B10.A mice which are resistant to autoimmune myocarditis. The eluted antibodies recognize fewer cardiac antigens than are recognized by circulating antibodies. These results provide an opportunity to examine the role of autoantibodies in the pathogenesis of chronic myocarditis.
在心肌炎和心肌病患者中，循环中的心脏反应性抗体很常见。虽然这些观察结果支持自身免疫机制可能参与发病机制的假说，但此类证据大多是间接的。目前的研究表明，心脏反应性抗体可从患有感染后自身免疫性心肌炎的柯萨奇病毒B3感染的A/J小鼠心脏中洗脱出来，但不能从对自身免疫性心肌炎有抵抗力的感染B10.A小鼠心脏中洗脱出来。洗脱的抗体识别的心脏抗原比循环抗体识别的少。这些结果为研究自身抗体在慢性心肌炎发病机制中的作用提供了机会。
