公认的及已证实的抗抑郁药可减少沙丁胺醇引起的饮水行为。
Reduction of salbutamol-induced drinking by putative and proven antidepressants.
作者信息
Gard P R, Fawcett J P, Kerr K P
机构信息
School of Pharmacy, Central Institute of Technology, Wellington, New Zealand.
出版信息
Eur J Pharmacol. 1991 May 17;197(2-3):217-9. doi: 10.1016/0014-2999(91)90525-u.
Salbutamol-induced drinking was determined in rats after 4 days of twice daily treatment with the conventional and putative antidepressants desipramine, clenbuterol or salbutamol. Drinking was also determined 21 h after a single dose of the abovementioned drugs. Both chronic and acute administration of the drugs resulted in a significant reduction in the salbutamol-induced fluid intake. The results suggest that these drugs decrease beta 2-adrenoceptor activity, but that repeated administration is not a prerequisite for the effect.
在用传统的和假定的抗抑郁药地昔帕明、克伦特罗或沙丁胺醇每日两次治疗4天后，测定大鼠中沙丁胺醇诱导的饮水情况。在单次给药上述药物21小时后也测定饮水情况。药物的慢性和急性给药均导致沙丁胺醇诱导的液体摄入量显著减少。结果表明，这些药物会降低β2 -肾上腺素能受体活性，但反复给药并非产生该效应的必要条件。
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