Przegaliński E, Baran L, Siwanowicz J
Psychopharmacology (Berl). 1983;80(4):355-9. doi: 10.1007/BF00432120.
Several lines of evidence (binding studies, reduced responsiveness of brain adenylate cyclase to noradrenergic stimulation, electrophysiological data) indicate that chronic treatment with antidepressant drugs induces subsensitivity of central beta-adrenergic receptors. We studied the effect of acute (single dose) and chronic (14 days, twice daily) treatment with imipramine, desmethylimipramine, amitriptyline, fluvoxamine and citalopram (10 mg/kg, orally) on salbutamol-induced suppression of exploratory activity in rats. This effect of salbutamol was antagonized by chronic, but not acute treatment with antidepressants. Chronic treatment with antidepressants as a rule did not significantly affect exploratory activity. Our results may be regarded as functional evidence at the behavioural level for the subsensitivity of beta-adrenergic receptors.
多项证据（结合研究、脑腺苷酸环化酶对去甲肾上腺素能刺激的反应性降低、电生理数据）表明，抗抑郁药物的长期治疗会导致中枢β-肾上腺素能受体敏感性降低。我们研究了丙咪嗪、去甲丙咪嗪、阿米替林、氟伏沙明和西酞普兰（10mg/kg，口服）急性（单次给药）和慢性（14天，每日两次）治疗对沙丁胺醇诱导的大鼠探索活动抑制的影响。沙丁胺醇的这种作用被抗抑郁药物的慢性治疗而非急性治疗所拮抗。通常，抗抑郁药物的慢性治疗对探索活动没有显著影响。我们的结果可被视为β-肾上腺素能受体敏感性降低在行为水平上的功能证据。
