缓激肽和血管紧张素II通过释放前列腺素抑制兔耳动脉中的神经传递。

Bradykinin and angiotensin II inhibit neurotransmission in rabbit ear artery by releasing prostanoids.

作者信息

Rónai A Z

机构信息

Institute of Organic Chemistry, L. Eötvös University, Budapest, Hungary.

出版信息

Eur J Pharmacol. 1991 May 30;198(1):93-5. doi: 10.1016/0014-2999(91)90567-a.

DOI:10.1016/0014-2999(91)90567-a

PMID:1655480

Abstract

In isolated, perfused rabbit ear artery bradykinin, like [Met5]enkephalin and angiotensin II, inhibited neurogenic constrictions in concentrations lower than 10(-8) M without affecting the responses to exogenous norepinephrine. The IC50 value of bradykinin was 1.95 x 10(-10) M. The inhibitory action of bradykinin and angiotensin II but not of [Met5]enkephalin was reduced or even reversed by indomethacin pretreatment, suggesting that endogenous prostanoids are involved.

摘要

在离体灌注的兔耳动脉中，缓激肽与[Met5]脑啡肽和血管紧张素II一样，在浓度低于10(-8)M时可抑制神经源性收缩，而不影响对外源性去甲肾上腺素的反应。缓激肽的IC50值为1.95×10(-10)M。吲哚美辛预处理可降低甚至逆转缓激肽和血管紧张素II的抑制作用，但对[Met5]脑啡肽无此作用，提示内源性前列腺素参与其中。