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CD4+ T细胞辅助在癌症免疫及新型癌症疫苗研发中的作用。

The role of CD4+ T cell help in cancer immunity and the formulation of novel cancer vaccines.

作者信息

Assudani Deepak P, Horton Roger B V, Mathieu Morgan G, McArdle Stephanie E B, Rees Robert C

机构信息

School of Biomedical and Natural Sciences, Nottingham Trent University, Clifton Lane, NG11 8NS, Nottingham, UK.

出版信息

Cancer Immunol Immunother. 2007 Jan;56(1):70-80. doi: 10.1007/s00262-006-0154-6. Epub 2006 Mar 23.

DOI:10.1007/s00262-006-0154-6
PMID:16555057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11030950/
Abstract

Recent years have seen the unprecedented surge of interest in the role of CD4+ T cells and the role they play in the development of the immune response. In this symposium review, we examine the evidence for this and discuss their functions, particularly in respect to the cancer immunology, including CD4+CD25+ cells (Treg).

摘要

近年来，人们对CD4+ T细胞的作用及其在免疫反应发展中所起的作用产生了前所未有的浓厚兴趣。在本次研讨会综述中，我们审视了相关证据并讨论了它们的功能，特别是在癌症免疫学方面，包括CD4+CD25+细胞（调节性T细胞）。

相似文献

[1]
The role of CD4+ T cell help in cancer immunity and the formulation of novel cancer vaccines.

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[2]
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[4]
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[7]
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[8]
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本文引用的文献

[1]
CD25 expression is correlated with histological grade and response to denileukin diftitox in cutaneous T-cell lymphoma.

J Invest Dermatol. 2006-3

[2]
Regulatory T cells in immune surveillance and treatment of cancer.

Semin Cancer Biol. 2006-4

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Increased induction of allogeneic-specific cord blood CD4+CD25+ regulatory T (Treg) cells: a comparative study of naïve and antigenic-specific cord blood Treg cells.

Exp Hematol. 2005-12

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J Clin Invest. 2005-12

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IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.

Blood. 2006-3-15

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Role of regulatory T cells in human diseases.

J Allergy Clin Immunol. 2005-11

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Trends Immunol. 2005-12

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Semin Immunol. 2005-12

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

J Clin Invest. 2005-11

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