Winer Jeffery A
Division of Neurobiology, Department of Molecular and Cell Biology, University of California at Berkeley, 94720-3200, USA.
Hear Res. 2006 Feb;212(1-2):1-8. doi: 10.1016/j.heares.2005.06.014.
The status of the organization of the auditory corticofugal systems is summarized. These are among the largest pathways in the brain, with descending connections to auditory and non-auditory thalamic, midbrain, and medullary regions. Auditory corticofugal influence thus reaches sites immediately presynaptic to the cortex, sites remote from the cortex, as in periolivary regions that may have a centrifugal role, and to the cochlear nucleus, which could influence early central events in hearing. Other targets include the striatum (possible premotor functions), the amygdala and central gray (prospective limbic and motivational roles), and the pontine nuclei (for precerebellar control). The size, specificity, laminar origins, and morphologic diversity of auditory corticofugal axons is consonant with an interpretation of multiple roles in parallel descending systems.
本文总结了听觉皮质传出系统的组织状态。这些是大脑中最大的神经通路之一，与听觉和非听觉丘脑、中脑及延髓区域存在下行连接。因此，听觉皮质传出影响可到达紧邻皮质突触前的部位、远离皮质的部位（如可能具有离心作用的橄榄周区域）以及耳蜗核，后者可能影响听觉早期的中枢事件。其他靶点包括纹状体（可能具有运动前功能）、杏仁核和中央灰质（可能具有边缘和动机作用）以及脑桥核（用于小脑前控制）。听觉皮质传出轴突的大小、特异性、分层起源和形态多样性与平行下行系统中多种作用的解释相一致。
