Elchalal U, Dgani R, Zosmer A, Levi E, Rakovsky E, Lifschitz-Mercer B
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Gynecol Oncol. 1991 Jul;42(1):91-3. doi: 10.1016/0090-8258(91)90237-y.
Combined vaginal and vulvar malignant fibrous histiocytoma has not been reported previously. Radical vulvectomy with node dissection is the currently recommended therapy for a vulvar lesion of this type. We present a case with complete tumor regression after combined chemotherapy and radiotherapy. The surgical approach in our patient was inappropriate due to advanced disease. Follow-up examinations for 6 years after initiation of therapy showed no evidence of local recurrence or distant metastasis. Chemotherapy followed by radiotherapy should be considered as an alternative to surgery in patients with advanced vaginal and vulvar involvement and in patients in whom complex medical problems preclude extensive surgical procedures.
阴道和外阴联合恶性纤维组织细胞瘤此前未见报道。根治性外阴切除术加淋巴结清扫术是目前针对此类外阴病变推荐的治疗方法。我们报告了1例经联合化疗和放疗后肿瘤完全消退的病例。由于疾病进展，我们患者的手术方式并不恰当。治疗开始后6年的随访检查未发现局部复发或远处转移的迹象。对于阴道和外阴受累严重以及存在复杂医学问题而无法进行广泛手术的患者，应考虑化疗后放疗作为手术的替代方案。
