Halpern J, Kopolovic J, Catane R
Cancer. 1984 Jun 15;53(12):2661-2. doi: 10.1002/1097-0142(19840615)53:12<2661::aid-cncr2820531215>3.0.co;2-6.
Malignant fibrous histiocytoma (MFH), arising at the site of a sacral chordoma 8 years after massive radiotherapy, is described. Initially, the patient received 7000 rad to the sacral area and, on recurrence, 5 years later, an additional 4000 rad. Two years later, a sacral mass was noted again. Biopsy then revealed MFH; chest x-ray showed multiple lung metastases. A combination chemotherapy, consisting of cyclophosphamide, vincristine, adriamycin (doxorubicin), and DTIC, resulted in a 6 month partial response. Subsequently, the patient died because of progressive metastatic disease. At autopsy, 8 years after diagnosis, both the sacral lesion and the lung metastases proved to be MFH, and no residual chordoma was found.
本文描述了一例恶性纤维组织细胞瘤（MFH），该肿瘤发生于骶骨脊索瘤经大剂量放疗8年后的部位。最初，患者骶骨区域接受了7000拉德的放疗，5年后复发时又额外接受了4000拉德的放疗。两年后，再次发现骶骨肿物。活检显示为MFH；胸部X线显示多发肺转移。由环磷酰胺、长春新碱、阿霉素（多柔比星）和达卡巴嗪组成的联合化疗产生了6个月的部分缓解。随后，患者因进行性转移性疾病死亡。诊断8年后尸检发现，骶骨病变和肺转移灶均为MFH，未发现残留的脊索瘤。
