Xie Jingwu
University of Texas Medical Branch at Galveston, Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, 301 University Blvd, Galveston, TX 77555-1048, USA.
Future Oncol. 2005 Jun;1(3):331-8. doi: 10.1517/14796694.1.3.331.
Prostate cancer is the most common malignancy and the second leading cancer-related cause of death in men in the USA. Despite enormous efforts in understanding the molecular basis of prostate cancer, very little progress has been made in prevention and treatment of this often lethal cancer. Recent studies have demonstrated that hedgehog signaling is frequently activated in advanced or metastatic prostate cancers. With small molecule inhibitors available to analyze the hedgehog signaling pathway, a novel rationale for prostate cancer therapy can be devised.
前列腺癌是美国男性中最常见的恶性肿瘤，也是与癌症相关的第二大死因。尽管在了解前列腺癌的分子基础方面付出了巨大努力，但在这种往往致命的癌症的预防和治疗方面进展甚微。最近的研究表明，在晚期或转移性前列腺癌中，刺猬信号通路经常被激活。有了可用于分析刺猬信号通路的小分子抑制剂，就可以设计出一种治疗前列腺癌的新理论依据。
