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Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer.浓度依赖性伊曲康唑对非小细胞肺癌的早期抗血管和抗肿瘤作用。
Clin Cancer Res. 2020 Nov 15;26(22):6017-6027. doi: 10.1158/1078-0432.CCR-20-1916. Epub 2020 Aug 26.
2
Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade.独特的人类白细胞抗原（HLA）I 类等位基因种系表达和 DRB1 杂合性预测接受 PD-1/PD-L1 免疫检查点阻断治疗的非小细胞肺癌患者的结局。
J Immunother Cancer. 2020 Jun;8(1). doi: 10.1136/jitc-2020-000733.
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Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab.基线肠道微生物群可预测接受伊匹单抗治疗的转移性黑色素瘤患者的临床应答和结肠炎。
Ann Oncol. 2017 Jun 1;28(6):1368-1379. doi: 10.1093/annonc/mdx108.
4
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma.开放性、探索性 II 期临床试验：口服伊曲康唑治疗基底细胞癌。
J Clin Oncol. 2014 Mar 10;32(8):745-51. doi: 10.1200/JCO.2013.49.9525. Epub 2014 Feb 3.
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Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology.抗真菌药物的治疗药物监测（TDM）：英国医学真菌学会指南
J Antimicrob Chemother. 2014 May;69(5):1162-76. doi: 10.1093/jac/dkt508. Epub 2013 Dec 29.
6
Repurposing itraconazole as a treatment for advanced prostate cancer: a noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer.将伊曲康唑重新用于治疗晚期前列腺癌：转移性去势抵抗性前列腺癌男性患者的非比较随机 2 期试验。
Oncologist. 2013;18(2):163-73. doi: 10.1634/theoncologist.2012-314. Epub 2013 Jan 22.
7
Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer.伊曲康唑抑制非小细胞肺癌的血管生成和肿瘤生长。
Cancer Res. 2011 Nov 1;71(21):6764-72. doi: 10.1158/0008-5472.CAN-11-0691. Epub 2011 Sep 6.
8
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.伊曲康唑，一种常用的抗真菌药物，可抑制 Hedgehog 通路活性和肿瘤生长。
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Hedgehog signaling pathway: development of antagonists for cancer therapy.刺猬信号通路：用于癌症治疗的拮抗剂的研发
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Hedgehog signaling in prostate cancer.前列腺癌中的刺猬信号通路
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Drug exposure: still relevant after all these years.

作者信息

Gerber David E, Putnam William C

出版信息

Oncotarget. 2021 Apr 13;12(8):721-722. doi: 10.18632/oncotarget.27899.

DOI:10.18632/oncotarget.27899
PMID:33889295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8057278/
Abstract
摘要