Cavaliere Robert, Newton Herbert
Division of Neuro-Oncology, Department of Neurology, Ohio State University, Columbus, OH 43210, USA.
Expert Opin Pharmacother. 2006 Apr;7(6):749-65. doi: 10.1517/14656566.7.6.749.
Maximal surgical debulking and radiotherapy have been the cornerstone of therapy for high-grade gliomas. The impact of chemotherapy on outcome has been marginal and, until recently, its usage has been debatable. The development of new drugs and an improved understanding of chemoresistance have reinvigorated interest in this treatment modality. Furthermore, increasing knowledge of gliomagenesis has also led to novel non-cytotoxic approaches to targeting the molecular machinery that is responsible for tumour development and progression. These new strategies, which are currently being evaluated in clinical trials, provide new hope for the future.
最大限度的手术切除和放疗一直是高级别胶质瘤治疗的基石。化疗对治疗结果的影响微乎其微，直到最近，其使用仍存在争议。新药的研发以及对化疗耐药性的深入了解，重新激发了人们对这种治疗方式的兴趣。此外，对胶质瘤发生机制的认识不断增加，也催生了针对负责肿瘤发生和进展的分子机制的新型非细胞毒性方法。目前正在临床试验中评估的这些新策略，为未来带来了新的希望。
