Sato Hironori, Yokoyama Masaru
Center for Pathogen Genomics, National Institute of Infectious Diseases, Tokyo, Japan.
Uirusu. 2005 Dec;55(2):221-9. doi: 10.2222/jsv.55.221.
Actively replicating RNA viruses in nature are continually changing their genetic information by spontaneous mutations. These changes often result in alterations in immune-sensitivity, drug-sensitivity, cell-tropism, and host-range, causing uncontrollability of the pathogen and emerging/re-emerging infections. To better understand the virus changes and develop effective methods to control the moving targets, it is essential to obtain information on changes in viral genomes and proteins. Although information on genetic changes is being accumulated very rapidly, assessment of changes in protein structure and function still requires time-consuming works. In this review, we will overview mutation studies of human immunodeficiency virus and other RNA viruses. In addition, we will introduce recent advances in the computational science and its application on mutation studies and drug development.
自然界中正在积极复制的RNA病毒会通过自发突变不断改变其遗传信息。这些变化常常导致免疫敏感性、药物敏感性、细胞嗜性和宿主范围的改变，从而使病原体变得无法控制，并引发新出现或再次出现的感染。为了更好地了解病毒变化并开发控制这些移动靶标的有效方法，获取病毒基因组和蛋白质变化的信息至关重要。尽管关于基因变化的信息正在迅速积累，但对蛋白质结构和功能变化的评估仍然需要耗时的工作。在这篇综述中，我们将概述人类免疫缺陷病毒和其他RNA病毒的突变研究。此外，我们还将介绍计算科学的最新进展及其在突变研究和药物开发中的应用。
