病毒的基因组结构和生活方式如何影响其种群变异？

How does the genome structure and lifestyle of a virus affect its population variation?

作者信息

Safari Maliheh, Roossinck Marilyn J

机构信息

Department of Plant Pathology and Environmental Microbiology, Center for Infectious Disease Dynamics, Pennsylvania State University, USA.

Department of Plant Pathology and Environmental Microbiology, Center for Infectious Disease Dynamics, Pennsylvania State University, USA; Murdoch University, Perth, Western Australia, Australia.

出版信息

Curr Opin Virol. 2014 Dec;9:39-44. doi: 10.1016/j.coviro.2014.09.004. Epub 2014 Sep 20.

DOI:10.1016/j.coviro.2014.09.004

PMID:25243801

Abstract

Viruses use diverse strategies for their replication, related in part to the genome structure (double-stranded or single-stranded; positive sense or negative sense; RNA or DNA). During each round of replication, mutations are introduced in the viral genome and the mode of replication (stamping machine and geometric replication) may affect the population dynamics of the progeny virus. Our understanding of the relationships among genome strandedness, mode of replication and the population variation is still limited. Here we will review what is known about virus replication by stamping machine or geometric modes, and how that relates to the biology of single stranded versus double stranded RNA genomes. We will present how this may affect the mutation frequency and population dynamics. Finally the potential importance of the population dynamics in acute viruses and persistent viruses will be discussed.

摘要

病毒采用多种复制策略，部分与基因组结构有关（双链或单链；正链或负链；RNA或DNA）。在每一轮复制过程中，病毒基因组会引入突变，复制模式（冲压机式和几何复制式）可能会影响子代病毒的群体动态。我们对基因组链性、复制模式和群体变异之间关系的理解仍然有限。在此，我们将综述关于通过冲压机式或几何模式进行病毒复制的已知信息，以及这与单链和双链RNA基因组生物学的关系。我们将阐述这可能如何影响突变频率和群体动态。最后，将讨论群体动态在急性病毒和持续性病毒中的潜在重要性。