Siegel Richard M
Immunoregulation Unit, Autoimmunity Branch, NIAMS, National Institutes of Health, Building 10 Room 9N238, Bethesda, Maryland 20892, USA.
Nat Rev Immunol. 2006 Apr;6(4):308-17. doi: 10.1038/nri1809.
Caspases are responsible for crucial aspects of inflammation and immune-cell death that are disrupted in a number of genetic autoimmune and autoinflammatory diseases. The caspase family of proteases can be divided into pro-apoptotic and pro-inflammatory members based on their substrate specificity and participation in separate signalling cascades. However, as discussed here, evidence has emerged over the past few years that a number of the caspases thought to be involved solely in apoptosis also contribute to specific aspects of immune-cell development, activation and differentiation, and can even protect cells from some forms of cell death.
半胱天冬酶负责炎症和免疫细胞死亡的关键环节，而在许多遗传性自身免疫性疾病和自身炎症性疾病中，这些环节都受到了破坏。蛋白酶半胱天冬酶家族可根据其底物特异性以及参与不同的信号级联反应，分为促凋亡成员和促炎成员。然而，正如本文所讨论的，在过去几年中出现的证据表明，一些原本被认为仅参与细胞凋亡的半胱天冬酶，也在免疫细胞发育、激活和分化的特定方面发挥作用，甚至可以保护细胞免受某些形式的细胞死亡。
