State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Functional Laboratory, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
Apoptosis. 2023 Apr;28(3-4):293-312. doi: 10.1007/s10495-022-01807-z. Epub 2023 Jan 16.
Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has been shown that osteoclasts, osteoblasts, macrophages, chondrocytes, periodontal and gingival cells may be involved in bone loss linked with pyroptosis. So far, the involved mechanisms have not been fully elucidated. In this review, we introduced the related cells involved in the pyroptosis associated with bone loss and summarized the role of these cells in the bone metabolism during the process of pyroptosis. We also discuss the clinical potential of targeting mechanisms in the osteoclasts, osteoblasts, macrophages, chondrocytes, periodontal and gingival cells touched upon pyroptosis to treat bone loss from bone metabolic diseases as well as the challenges of avoiding potential side effects and producing efficient treatment methods.
细胞焦亡可能与骨代谢疾病导致的骨丢失有关，对人们的健康和生活造成负面影响。目前已经证实破骨细胞、成骨细胞、巨噬细胞、软骨细胞、牙周及牙龈细胞可能与细胞焦亡相关的骨丢失有关。但是，其中涉及的机制尚未完全阐明。在这篇综述中，我们介绍了与骨丢失相关的细胞焦亡，并总结了这些细胞在细胞焦亡过程中对骨代谢的作用。我们还讨论了针对破骨细胞、成骨细胞、巨噬细胞、软骨细胞、牙周及牙龈细胞中涉及的机制来治疗骨代谢疾病导致的骨丢失的临床潜力，以及避免潜在副作用和产生有效治疗方法的挑战。
