Elgorashi Esameldin E, Stafford Gary I, Jäger Anna K, van Staden Johannes
Research Center for Plant Growth and Development, School of Biological and Conservation Sciences, University of Kwa-Zulu Natal, Scottsville, South Africa.
Planta Med. 2006 Apr;72(5):470-3. doi: 10.1055/s-2005-916251.
Twenty-one Amaryllidaceae alkaloids isolated from different Amaryllidaceae species were investigated for their affinity to the serotonin reuptake transport protein and for GABA(A)-benzodiazepine receptor binding. Cherylline (21), crinamine (7), crinine (1), epibuphanisine (2), epivittatine (6), maritidine (11), O-methylmaritidine (12), powelline (3), 1-O-acetyllycorine (18) and tazettine ( 13) showed affinity to the serotonin reuptake transport protein. Cherylline (21) and epivittatine (6) yielded the highest activity among the group. No GABA(A)-benzodiazepine receptor binding activity was exhibited by the alkaloids tested.
