Veterans Administration Center, Los Angeles, California 90073.
Infect Immun. 1970 Jun;1(6):532-7. doi: 10.1128/iai.1.6.532-537.1970.
Rapidly growing Streptococcus faecalis was found to be markedly susceptible to the bactericidal activity of normal rat and rabbit sera, whereas stationary-phase organisms were resistant. In contrast, human serum killed neither phase organism. Further, human serum was found to interfere with killing by rabbit serum. The serosusceptible, rapidly growing organisms were less virulent than the seroresistant, stationary-phase organisms. This was tested by production of pyelonephritis in the rat after intravenous inoculation of the organism. Renal bacterial content over a period of 4 weeks was significantly less in those animals which had received rapidly growing organisms.
迅速生长的粪肠球菌明显易受正常大鼠和兔血清的杀菌活性影响，而静止期的细菌则具有抗性。相比之下，人血清对这两种细菌均无杀伤作用。此外，人血清还被发现会干扰兔血清的杀菌作用。血清敏感的、迅速生长的细菌比血清耐药的、静止期的细菌的毒力要弱。这通过静脉接种细菌后在大鼠中引起肾盂肾炎来进行测试。在 4 周的时间内，接受迅速生长的细菌的动物的肾脏细菌含量明显减少。
