豚鼠弓形体病迟发型超敏反应的体内和体外研究。
In Vivo and In Vitro Studies of Delayed-Type Hypersensitivity to Toxoplasma gondii in Guinea Pigs.
机构信息
Department of Medical Microbiology, University of Wisconsin Medical School, Madison, Wisconsin 53706.
出版信息
Infect Immun. 1971 Feb;3(2):260-7. doi: 10.1128/iai.3.2.260-267.1971.
Delayed-type hypersensitivity develops late in the course of human toxoplasmosis, and a positive skin test is of some value for implicating chronic or eliminating acute forms of toxoplasmosis as a cause of disease. Toxoplasma-infected guinea pigs were studied to determine the onset and development of delayed-type hypersensitivity. Both the toxoplasmin skin test and the in vitro macrophage migration inhibition technique indicated that delayed hypersensitivity to toxoplasma antigen existed as early as 1 week after infection. The mechanism responsible for the observed inhibition of macrophage migration in vitro appeared to be an inhibitory factor(s) released from sensitized lymphoid cells in the presence of antigen.
迟发型超敏反应在人类弓形体病的病程后期发展，阳性皮肤试验对提示慢性或排除急性弓形体病作为疾病病因具有一定价值。本研究旨在探讨感染弓形体的豚鼠迟发型超敏反应的发生和发展。弓形虫菌素皮肤试验和体外巨噬细胞移动抑制试验均表明，感染后 1 周即可出现针对弓形虫抗原的迟发型超敏反应。体外观察到的巨噬细胞迁移抑制的机制似乎是在抗原存在的情况下，致敏淋巴细胞释放的一种（或多种）抑制因子。
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